本期导读
●生物材料应用与神经再生：
神经元纤维支架界面的结构要求；
神经组织培养工具：冷冻凝胶支架
●基因治疗与神经再生：
新兴基因沉默剂：DNA酶；
●微生物群，益生菌治疗与神经再生：
针对微生物群策略促进神经再生；
微生物群失调与神经炎症之间的关联；
肠道微生物组：退化和再生之间的平衡
●视网膜疾病的最新治疗展望：
环状RNA治疗策略；
治疗退行性视网膜疾病神经保护剂的最新进展；
骨髓来源单核干细胞治疗视网膜退变。
综述
Neuroprotective agents effective against radiation damage of central nervous system
对中枢神经系统辐射损伤有效的神经保护剂
Mria Lalkoviov
Neuroprotective effects of naturally sourced bioactive polysaccharides: an update
有神经保护作用的天然生物活性多糖：新观点
Xiao-Lan Xu, Song Li, Rong Zhang, Wei-Dong Le
Alerting effects of light in healthy individuals: a systematic review and meta-analysis
光照对健康人警觉的影响：系统综述与meta分析
Yi-Man Mu, Xiao-Dan Huang, Sui Zhu, Zheng-Fang Hu, Kwok-Fai So, Chao-Ran Ren, Qian Tao
Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements
周围神经系统中的神经元纤维支架界面：对结构要求的看法
Sanaz Behtaj, James A. St John, Jenny A. K. Ekberg, Maksym Rybachuk
Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies
用于再生疗法临床前测试的非人灵长类多能干细胞
Ignacio Rodrguez-Polo, Rdiger Behr
Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease
外泌体在帕金森病炎症反应中的作用
Ke-Lu Li, Hong-Yan Huang, Hui Ren, Xing-Long Yang
Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity
星形胶质细胞保护多巴胺能神经元免受氨基色素神经毒害
Juan Segura-Aguilar, Bengt Mannervik, Jos Inzunza, Mukesh//www.58yuanyou.com Varshney, Ivan Nalvarte, Patricia Mu原由网oz
Intranasal neprilysin rapidly eliminates beta-amyloid plaques, but causes plaque compensations: the explanation why the beta-amyloid cascade may fail?
鼻腔内的eprilysin能迅速消除-淀粉样蛋白斑块，但会引起斑块的补偿：解释为什么-淀粉样蛋白级联可能失败？
Christian Humpel
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer's disease
重新利用的抗癌表皮生长因子受体抑制剂：阿尔茨海默病的神经保护作用机制
Heba M. Mansour, Hala M. Fawzy, Aiman S. El-Khatib, Mahmoud M. Khattab
Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?
维生素D在多发性硬化的治疗中是否存在机会窗口？
Sofia Fernanda Gonalves Zorzella-Pezavento, Luiza Ayumi Nishiyama Mimura, Marina Bonifcio Denadai, William Danilo Fernandes de Souza, Thais Fernanda de Campos Fraga-Silva, Alexandrina Sartori
Emerging roles of circular RNAs in retinal diseases
环状RNA在视网膜疾病中的新兴作用
Aneliya Hanineva, Karen Sophia Park, Joshua J. Wang, Margaret M. DeAngelis, Michael H. Farkas, Sarah X. Zhang
Recent developments of neuroprotective agents for degenerative retinal disorders
治疗退行性视网膜疾病的神经保护剂的最新进展
Kepeng Ou, Youjian Li, Ling Liu, Hua Li, Katherine Cox, Jiahui Wu, Jian Liu, Andrew D. Dick
Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations
骨髓来源单核干细胞治疗视网膜变性
Diego Garca-Ayuso, Johnny Di Pierdomenico, David Garca-Bernal, Manuel Vidal-Sanz, Mara P. Villegas-Prez
观点
Inhibition of central axon regeneration: perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury
桥接阻断轴突再生的细胞外和细胞内机制：从七鳃鳗脊髓损伤中硫酸软骨素蛋白聚糖的角度
Jianli HtlDFvCIu, Li-Qing Jin, Michael E. Selzer
Neuronal circuitry reconstruction after stem cell therapy in damaged brain
受损大脑干细胞治疗后的神经元回路重建
Daniel Tornero
N-acetyl-L-leucine: a promising treatment option for traumatic brain injury
N-乙酰-L-亮氨酸：创伤性脑损伤的一种有前途的治疗选择
Chinmoy Sarkar, Marta M. Lipinski
Chronic traumatic encephalopathy: genes load the gun, repeated concussion pulls the trigger
慢性创伤性脑病：基因装枪，反复震荡扣动扳机
Robert Vink, Frances Corrigan
Heme as an inducer of cerebral damage in hemorrhagic stroke: potential therapeutic implications
血红素作为出血性卒中脑损伤的诱导剂：潜在治疗意义
Luiz Ricardo da Costa Vasconcellos, Pedro Moreno Pimentel-Coelho
Can we promote neural regeneration through microbiota-targeted strategies? Introducing the new concept of neurobiotics
我们能否通过针对微生物群的策略促进神经再生？ 神经生物学的新概念
Celia Herrera-Rincon, Julia Murciano-Brea, Stefano Geuna
Perspective on 原由网the relationship between microbiota dysbiosis and neuroinflammation: probiotics as a treatment option
微生物群失调与神经炎症之间的关系：益生菌作为一种治疗选择
Chiao Ng, Zahoor A. Shah
Gut microbiome: a balancing act between degeneration and regeneration
肠道微生物组：退化和再生之间的平衡
Nitin Saksena, Matt Keon
Early life stress-induced neuroinflammation and neurological disorders: a novel perspective for research
早期生活应激引起的神经炎症和神经疾病：研究新视角
Clarissa Catale, Valeria Carola, Maria Teresa Viscomi
The blood-brain barrier models to study Apolipoprotein E genotypes in Alzheimer’s disease
用于研究阿尔茨海默病中载脂蛋白 E 基因型的血脑屏障模型
Irundika HK Dias, Rachelle Taiwo, Dan Ma
Endocannabinoid metabolism and Alzheimer’s disease
内源性大麻素代谢与阿尔茨海默病
Chu Chen
Glucose metabolism in amyotrophic lateral sclerosis: it is bitter-sweet
肌萎缩侧索硬化中的葡萄糖代谢：苦乐参半
Titaya Lerskiatiphanich, Jianina Marallag, John D. Lee
K+/Cl− co-transporter-2 upmodulation: a multi-modal therapy to treat spinal cord injury
钾氯共转运体2上调：一种治疗脊髓损伤的多模式疗法
Shane V. Hegarty, Joanna Stanicka
Opportunities for agent based modeling of retinal stem cell transplantation
基于代理的视网膜干细胞移植建模机会
Larissa M. DePamphilis, Troy Shinbrot, Maribel Vazquez
Cryogel scaffolds: soft and easy to use tools for neural tissue culture
冷冻凝胶支架：柔软且易于使用的神经组织培养工具
Ben Newland, Katherine R. Long
DNAzyme as a rising gene-silencing agent in theranostic settings
DNA酶作为一种新兴的基因沉默剂在治疗领域的应用
Nan Zhang
研究原著
脑损伤与神经再生
Stellate ganglion block rtlDFvCIeduces inflammation and improves neurological function in diabetic rats during ischemic stroke
星状神经节阻滞有助于改善糖尿病缺血性脑卒中的神经功能及炎症反应
Ting-Ting Li, Qiang Wan, Xin Zhang, Yuan Xiao, Li-Ying Sun, Yu-Rong Zhang, Xiang-Nan Liu, Wan-Chao Yang
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice
低强度经颅聚焦超声刺激保护脑缺血后血脑屏障的完整性
Li-Dong Deng, Lin Qi, Qian Suo, Sheng-Ju Wu, Muyassar Mamtilahun, Ru-Bing Shi, Ze Liu, Jun-Feng Sun, Yao-Hui Tang, Zhi-Jun Zhang, Guo-Yuan Yang, Ji-Xian Wang
Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice
尿石素A可减轻创伤性脑损伤后血脑屏障破坏及神经元凋亡
Qiu-Yuan Gong, Lin Cai, Yao Jing, Wei Wang, Dian-Xu Yang, Shi-Wen Chen, Heng-Li Tian
脊髓损伤与神经再生
MicroRNA-101a-3p mimic ameliorates spinal cord ischemia/reperfusion injury
microRNA-101a-3p模拟物可减轻脊髓缺血再灌注损伤
Zai-Li Zhang, Dan Wang, Feng-Shou Chen
Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction
新型上行神经调控：神经根磁刺激促进电生理修复和皮质突触重建改善脊髓损伤后的运动功能
Ya Zheng, Dan Zhao, Dong-Dong Xue, Ye-Ran Mao, Ling-Yun Cao, Ye Zhang, Guang-Yue Zhu, Qi Yang, Dong-Sheng Xu
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury
芦可替尼可降低创伤性脊髓损伤后的继发性病变
Zhan-Yang Qian, Ren-Yi Kong, Sheng Zhang, Bin-Yu Wang, Jie Chang, Jiang Cao, Chao-Qin Wu, Zi-Yan Huang, Ao Duan, Hai-Jun Li, Lei Yang, Xiao-Jian Cao
周围神经损伤与神经再生
The proteome of distal nerves: implication in delayed repair and poor functional recovery
远端神经蛋白质组在延迟修复和不良功能恢复中的意义
Song Guo, Raymond M. Moore, M. Cristine Charlesworth, Kenneth L. Johnson, Robert J. Spinner, Anthony J. Windebank, Huan Wang
Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury
持续释放血管内皮生长因子的甲基丙烯酸酐化明胶水凝胶可加速挤压损伤周围神经的再生
Wanlin Xu, Yifan Wu, Hao Lu, Yun Zhu, Jinhai Ye, Wenjun Yang
Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats
聚多巴胺修饰甲壳质小间隙神经套管负载外泌体缓慢释放可促进周围神经的再生
Ci Li, Song-Yang Liu, Meng Zhang, Wei Pi, Bo Wang, Qi-Cheng Li, Chang-Feng Lu, Pei-Xun Zhang
Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury
释放一氧化氮的硅纳米颗粒促进急性周围神经压迫损伤后血管重建和功能恢复
Jung Il Lee, Ji Hun Park, Yeong-Rim Kim, Kihak Gwon, Hae Won Hwang, Gayoung Jung, Joo-Yup Lee, Jeong-Yun Sun, Jong Woong Park, Jae Ho Shin, Myoung-Ryul Ok
神经退行性疾病与神经再生
(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice
(D-Ser2)胃泌酸调节素可恢复阿尔茨海默病转基因小鼠的海马突触功能及theta节律
Guang-Zhao Yang, Qi-Chao Gao, Wei-Ran Li, Hong-Yan Cai, Hui-Min Zhao, Jian-Ji Wang, Xin-Rui Zhao, Jia-Xin Wang, Mei-Na Wu, Jun Zhang, Christian Hlscher, Jin-Shun Qi, Zhao-Jun Wang
Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer’s disease
水通道蛋白 4 缺失可抵消自主运动对阿尔茨海默病模型的有益影响
Yun Liu, Pan-Pan Hu, Shuang Zhai, Wei-Xi Feng, Rui Zhang, Qian Li, Charles Marshall, Ming Xiao, Ting Wu
Abnormal characterization of dynamic functional connectivity in Alzheimer’s disease
阿尔茨海默病动态功能连接的异常表征
Cui Zhao, Wei-Jie Huang, Feng Feng, Bo Zhou, Hong-Xiang Yao, Yan-E Guo, Pan Wang, Lu-Ning Wang, Ni Shu, Xi Zhang
